The plague(I am assuming you are referring to the Bubonic Plague) was not stopped, in a sense, every. It still exists today and is just as deadly as it was throughout history, thought modern antibiotics have greatly reduced its potential to be cause destruction on the levels we hear about during any of the historical epidemics. What cause the epidemics of the black death to gradually decrease throughout England was accidental. First though, I should explain a few important facts about the plague. For the most part the plague can only be naturally transmitted by the black rat flea. Human to human transmission is very rare, and only occurs often when it the form of plague is pnuemonic. Even than though human to human transmission is rare. The outbreaks within manchurian logging communities around the early 1900s attest to this. Large groups of individuals were living in very unsanitary and close quarters, some of which had been infected with pnuemonic plague. Despite the regular contact with one another the rate of transmission was low. The plague is spread when an infected rat flea's rat host dies of the disease and the flea is forced to seek a blood supply elsewhere. The flea turns to the human population and begins to feed on humans. Unfortunately Yersina Pestis(bubonic plague) causes a blockage within the fleas stomach and forces it to regurgitate the blood it attempts to swallow. when this occurs it causes large amounts of the bacteria to be injected into the human blood stream. But for this cycle to work there has to be a large black rat population because the black rat flea is the flea that transmits the disease. During the 1600s, and following the fire of London many of the buildings within London and England as a whole began to be built with bricks. The black rat is not a good climber and therefore many black rats had difficulty finding homes and were slowly replaced by the brown rat, a rat that is a better climber than the black rat. This led to a decrease in the transmitting agents of the black death, and therefore a decrease in outbreaks. The Fire of London could be cited as perhaps a very indirect cause, but then you come to the question of whether the fire of London caused a trend in England to switch from wood to brick as the preferred building material. Or if the fire of London merely cause the transition to occur much more rapidly within that city as an isolated occurance.