Yes! I work for an Aboriginal organization in the Northwest Territories (Canada) and have delved into much literature regarding the interaction of Inuits and First Nations/Metis.

Now, I must first say this spiel prior to getting into the facts. A lot of the literature on the interaction between these groups comes from 18th and 19th century 'explorers', thus, when viewed in the contemporary, they are considered to be colonial, racist, and romantic (if you wanted to sell a good subarctic /arctic book, you better have a good story about adventure/near death/etc).

Historically (and in the contemporary), Inuit, once the ice melts along the continental coast, head inland to their summer camps to fish (arctic char) and to collect supplies near the the 'tree line' (not really a distinct line, but more a large swath of subarctic area). The area of "little sticks" was good place to scrounge for wood to fashion into tools. In this area they would meet First Nations (such as the Chipewyan, Dene, etc).

A famous documentation regarding such a specific event is from Samual Hearne (albeit post contact, or after Columbus). He ventured to the mouth of the Coppermine River with a group of Chipewyan. Along the way, it became apparent that his guides had an ulterior motive (rather than merely guiding Hearne), and that was to settle bad blood with the Inuit. Upon finding the Inuit at their summer camp along the Coppermine River, the Chipewyan proceeded to massacre every person in the camp, regardless of age or gender.

What occurred became known as the Bloody Falls Massacre. Now, as mentioned above, some historians are skeptical about some of the details of Hearne's account, but nonetheless, the event did occur and is known in Aboriginal oral tradition. The entire account can be read in Hearne's book: (A journey from Prince of Wales's fort in Hudson Bay to the northern ocean, in the years 1769, 1770, 1771, and 1772.).

As noted by Hearne, while in this boundary area, it appears that Aboriginal groups would have disputes that often or not led to aggressive actions by both sides. It seems that it became a tit for tat, were each side would have an oral tradition of the other attacking, enslaving, or generally disrespecting them. This would lead to further distrust and facilitate the possibility of future violent altercations.

Alternately, this view is not taken as absolute. Most historians see, as with anything, a spectrum of issues occurring, particularly with the advent of the fur trader. Post-contact, a number of the groups, such as the Chipewyan, became intermediaries between the fur traders and the Inuit. Evidently, the Chipewyan understood the trade and worked as hard as possible to secure their role as intermediaries. They did not want the fort traders to venture further north or inland and cut them out of a very powerful role. Thus, there is some advantage in noting that the people who were beyond the Chipewyan as nasty, brutish, and savage. This idea would optimistically (for the Chipewyan) keep the fur traders in their comfortable posts/forts on Hudson's Bay, while allowing the Chipewyan to continue consolidating power as an intermediary trader between the Dene, Cree, Inuit, etc.

Anyhow, the question is rather large and impossible for me to answer in one post. I would suggest that you look into further resources, both historical and anthropological. There really is a slew of information on the topic, from scholarly articles to explorer journals.

Further readings:

Chipewyan, Cree and Inuit Relations West of Hudson Bay, 1714-1955 James G. E. Smith Ethnohistory Vol. 28, No. 2 (Spring, 1981), pp. 133-156

Trans-Indian Identity and the Inuit “Other”: Relations between the Chipewyan and Neighboring Aboriginal Communities in the Eighteenth Century SE Roberts - Ethnohistory, 2010 -

Samuel Hearne and Indian-Inuit hostility Y Csonka - Polar Record, 1993 - Cambridge Univ Press

Free Online Journals (these all have reference to Inuit/First Nations)

Franklin, John. (1823). Narrative of a Journey to the Shores of the Polar Sea in the Years 1819-22

Dease, Peter Warren (2002). William Barr. ed. From Barrow to Boothia: The Arctic Journal of Chief Factor Peter Warren Dease

Back, George. (1835). Narrative of the Arctic land expedition to the mouth of the Great Fish River, and along the shores of the Arctic Ocean in the years 1833, 1834, and 1835.

Mackenzie, Alexander. Voyages from Montreal Through the Continent of North America to the Frozen and Pacific Oceans in 1789 and 1793

Hearne, Samuel. A journey from Prince of Wales's fort in Hudson Bay to the northern ocean, in the years 1769, 1770, 1771, and 1772