I am currently enrolled in an American Constitutional History class at my college and this is a question my group has been assigned as part of our final. Our trouble is, because the Bill of Rights was originally written as a check on federal power, that we're having trouble just limiting our scope. Part of the assignment is to connect the question to relevant political issues today, so we were going to take a look at legislation regarding whistelblowers as well as food libel laws, since these are both instances of tensions between free speech and corporate rights. Thanks so much in advance!
You may also want to try /r/Ask_Politics.