I'm not entirely clear on what you mean by 'orchestrated from Munich', so I'll leave that aside for the moment.

To the second part of your question: you have to look at the Holocaust as happening in three broad phases —

1. the early efforts to marginalise, persecute and remove from Germany the Jewish population, which start in (at least) 1933 and pick up pace with the introduce Nuremberg Race Laws in 1935.
2. widespread but generally ad-hoc massacres of Jewish populations in Eastern Europe and the Caucasus by the Einsatzgruppen during Operation Barbarossa, and the 'ghettoisation' of existing Jewish populations in German-occupied territories like Poland.
3. the 'Final Solution to the Jewish Problem', which comprises a systematic, state-wide effort to exterminate — not just displace — the Reich's Jewish population, which dates from 1942.

The pivotal moment in the history of the Holocaust — that is, the moment when genocide/mass extermination becomes formal state policy — is the Wannsee Conference in January 1942 (the minutes of which were crucial evidence at the Nuremberg trials.)

In an hour and a half at Wannsee, a working group of senior Nazi officials from across multiple departments — from the SS and security forces to the Reich economic offices, interior ministry and Chancellery — led by Reinhard Heydrich (then-head of the RHSA) agreed a formalised, state-wide policy of genocide. The minutes are couched in deliberately euphemistic, bureaucratic language:

Under proper guidance, in the course of the final solution the Jews are to be allocated for appropriate labor in the East. Able-bodied Jews, separated according to sex, will be taken in large work columns to these areas for work on roads, in the course of which action doubtless a large portion will be eliminated by natural causes.

The possible final remnant will, since it will undoubtedly consist of the most resistant portion, have to be treated accordingly, because it is the product of natural selection and would, if released, act as a the seed of a new Jewish revival (see the experience of history.)

In the course of the practical execution of the final solution, Europe will be combed through from west to east. Germany proper, including the Protectorate of Bohemia and Moravia, will have to be handled first due to the housing problem and additional social and political necessities.

The evacuated Jews will first be sent, group by group, to so-called transit ghettos, from which they will be transported to the East.

Despite the ambiguous language, the inference of "evacuation to the east" in the context of a "final solution to the Jewish problem" should be reasonably clear: the majority of the concentration camps constructed specifically for the purpose of extermination (as opposed to forced labour) were in Poland: Bełżec, Auschwitz-Birkenau, Sobibór, Treblinka and Chełmno, among others.

Heydrich, who as head of the RHSA oversaw (among other departments) the Gestapo and SD, is generally regarded as one of the primary administrators of the Holocaust until his assassination in June 1942. The primary strategic/operational organiser of the Holocaust is generally seen to be Himmler, as head of the SS and Heydrich's immediate superior.

In terms of understanding Hitler's direct role in the Holocaust, you have to consider Nazi Germany as an enormous bureaucracy, with a pyramidal structure: between the institutions of state, party and military, there's a huge, interconnected web of fiefdoms and overlapping responsibilities.

A key characteristic of Nazi Germany was Hitler's tendency to surround himself with capable, powerful administrators like Himmler who built their own mini-empires and jostled for position with one another. There's plenty of evidence that Hitler conceived, ordered and remained well-informed about the progress of the Final Solution — but in terms of direct, ongoing personal involvement, my understanding has always been that the administration and operational orchestration of the genocide was carried out primarily by Himmler and the SS.

Hitler was an ideologue, and a micromanager in some areas — military strategy, for example, but I haven't read much to suggest that the same was true of the Holocaust. The consensus seems to be that Hitler defined a strategic goal, and expected his subordinates to achieve it.