Yes, there was.

If you look here at this calculated eclipse chart, you'll find that a partial lunar eclipse, visible from Constantinople, occurred on May 22, 1453 - only a week before the fall of the city. The maximum of this eclipse would have been at around 8:19 in the evening, which would have been very prominently visible in the Eastern sky to both the Byzantine/Italian defenders and the attacking Ottomans.

For the Ottomans (who were facing the East, towards the Theodosian Walls), the Blood Moon would have been seen rising above the city, which would have provided a very inspiring sight indeed, since the symbol of Constantinople was the crescent moon - to see it bleeding would have been interpreted as a sign of fortune. Likewise, it was a dreadful sight for the defenders to behold and Western chroniclers report that it was interpreted as a sign of impending doom.