Given the estimated population of the Americas before the exchange of old-world diseases, would colonization have failed if the native peoples had been more resistant to such diseases and survived in large?

Sorry, but your submission has been removed because we don't allow hypothetical questions. If possible, please feel free to rephrase the question so that it does not call for such speculation, and resubmit Otherwise, this sort of thing is better suited for /r/HistoryWhatIf.