The Sonderkommando at Auschwitz-Birkenau staged an uprising in 1944, which killed 3 SS guards and prompted a brief mass break-out There were uprisings, and the 1944 Auschwitz uprising is probably the most famous and successful, and spawned the movie The Grey Zone. And as the film notes there were several small-scale uprisings by prisoners at Auschwitz, but a combination of factors meant they were never successful: while the prisoners had the numbers, they were too weak to properly do anything, as well as unable to properly organise any large rebellion. Also consider that large numbers of them were women, children or the elderly, as opposed to SS guards who were trained militarily.