By the homefront in this question, I mean the pre-conquest territories of the Kingdom of Macedon, the capital and surrounding areas.
While Alexander was on campaign, domestic affairs were largely handled by Antipater, a trusted court official and one of the major players in the funerary games after Alexander's death. In fact, around the time of Alexander's death, one of the popular theories for the cause was that one of Antipater's sons had poisoned the emperor. This was attributed to Antipater's renowned conservatism and his dislike of the Hellenistic tendencies of Alexander, which he viewed as being diametrically opposed to traditional Macedonian customer and values.