Yes there are several, some of which were fairly notorious in their day.

Baron Gilles de Rais, comrade of Joan of Arc and the Marshall of France (1429-39), committed several dozen murders, perhaps hundreds. The victims were young children, whom he would abduct, torture, rape and then dismember, with a close circle of accomplices. He cremated the remains of many victims to avoid detection, although a mass grave was discovered containing some 40 children, whom he had previously sodomized. De Rais was exposed under investigation by the Bishop of Nantes and hanged in 1440.

Peter Stumpp, known also as The Bedburg Werewolf, was active in the Holy Roman Empire during the 1570s and 80s. A serial killer and cannibal, he murdered and ate at least a dozen people during his life, including his own son. Stumpp claimed to have been in league with Satan, who had given him the ability to transform into a wolf. He was broken on the wheel and beheaded in 1589.

Peter Niers, a highwayman and supposed occultist, was also active in the Holy Roman Empire. He allegedly killed hundreds of people, although he certainly murdered dozens of pregnant women and their fetuses. He escaped from custody after his first arrest and became infamous for his cannibalism. Niers was broken on the wheel and quartered in 1581.

Björn Pétursson was an Icelandic farmer who routinely robbed and murdered those on the road around his home. Today he is still pretty famous in Iceland and probably killed around a dozen people, before hiding their corpses in outbuildings and bodies of water. Pétursson was tried and later beheaded in 1596.

There is also a famous French case which I have read about several times but do not know enough about to comment on its veracity. It involves Philibert Montot, Pierre Bourgot, and Michel Verdun who, amid bizarre claims of black magic and lycanthropy, committed several murders. The victims were usually children. All three were executed and entered French folklore as The Poligny Werewolves.

Edit: Typing.