Recent discussion of this. Short answer: no, because these programs focused solely on phenotypes (not genotypes), were often ill-constructed in that respect due to lack of knowledge (they were crudely applied), and often were applied to non-reproducing populations anyway (the institutionalized). Relative to their total populations, even the most expansive programs were drops in a bucket. The most you could say for them is that they would affect the phenotypic expression of certain traits for that generation (if you kill everyone with X, you will suddenly have nobody with X around), but the underlying "gene pool" would not be particularly affected (which means in the next generation, X shows up again). One can compare this sort of thing with the efforts on the island of Cyprus to eliminate thalassemia — the gene pool here does not change, even though the amount of expression does change.