The devastation of the Dust Bowl was magnified greatly for Native Americans for several reasons. The biggest affect was starvation and neglect as the native americans had been increasingly forced to accept a lifestyle entirely dependant on the federal government. As crops failed the federal government refused to uphold foot allotments and so poverty and hunger increased on reservations

In many cases Native Americans were blamed as a scape-goat for the loose top soils. the federal government tried to claim that the indigenous land use was the cause of the dust bowl. This led to nations like the Comanche who had thousands of their livestock taken away from them. This was devastating for them as the livestock is integral to their culture and social status.

The dust-bowl also served as an excuse to further curtail the land rights of native americans. Because native americans were blamed for the issue, their rights to graze livestock on federal lands promised to them in treaties were revoked by the Taylor Grazing Act in 1934. This further reduced the Native American's ability to be independent from the government.

The water management plans of the 1940s created tension between the government and Native Americans. in 1945 the Garrison Dam at the Fort Berthold Reservation was constructed without the consent of the native americans who owned the land. This led to 325 tribal families being forcefully removed from their land.

as with most of american history, Native Americans were pushed to the fringes of society and repeatedly blamed for any problems while simultaneously suffering more than anyone else.