The pilgrimage bucket list of 15th-16th century merchant Jacques Lesaige included Santiago de Compostella, Loreto (Italy--the Marian shrine Basilica della Santa Casa), Rome, and Jerusalem.

As far as routes to Jerusalem, the overland options of the early Middle Ages phased out (Ottomans on one hand; better ships on the other). Most people seem to have departed through Venice on Venetian galleys. Some left from Marseilles and ran into trouble with the Barbary pirates/kidnappers. One pilgrim noted that he preferred to leave from "beautiful" Genoa because the Genoese had nicer ships. The ships would typically hug the European coast and make stops in the Balkans. Some pilgrimage accounts mention Cyprus. The Middle Eastern point was Alexandria (where Western merchants had an established section of the city) or Jaffa (which was ruins with a harbor, at least according to the European accounts). Nobody has good things to say about the medieval version of customs (a "swine cave"). From there some pilgrims made a stop in Ramla to visit St. George's supposed grave; others went directly to Jerusalem.