it's clear that all Cherokees didn't live in tipis.

To begin with, no one in the Cherokee Nation lived in tipis. Not at the time of Removal, and not before. Tipis are a feature in Plains architecture. While there are some analogues east of the Mississippi, they're few and far between, mostly concentrated in the areas adjacent to the Plains to the west and the Subarctic to the north. For the Cherokee, at the time of European contact, a family typically had two houses - one for winter and one for summer. The winter house was circular, usually about 10 feet in diameter but could be larger or smaller, with a domed or conical roof and thick daub walls. It was designed to trap heat - a task it did so well that Euroamericans who stayed in such houses complained that it was too hot for their clothes even during the coldest days of winter. The summer house was square or rectangular, 10-20 feet on a side, with high thatched roofs.

These were paired off within a village in the early colonial period, but through the 1700s, Cherokee villages became more dispersed and more and more people opted for single family homesteads. By the 1800s, homesteading was the norm. The winter house also became less common, entirely disappearing from many parts of the Cherokee Nation, as log cabins became the dominant type of housing for the Cherokee.

I know that farming [...] had been adopted

Farming was part of Cherokee life long before Europeans showed up in the Americas. The extent of Cherokee farmland actually shrunk during the 1700s with the dispersal of the towns. When people lived in towns, they could pull their resources and labor, especially when planting and harvesting. But has homesteading became more common, all the labor fell on a smaller number of individuals. Specifically women, since farming (and maintenance of a family's property in general) was considered under their authority.

Cherokee men during this period preferred to stay out of agriculture, though the introduction of European livestock created an interesting dilemma. Who should own these animals? Was it an extension of hunting and therefore a predominantly (but not exclusively) male activity? Or was it an extension of agriculture and therefore a predominantly (but not exclusively) female activity? Of course, as far as Euroamericans were concerned, both agriculture and animal husbandry were male activities and if Cherokee women wanted to be good Christian housewives, they should be busying themselves with cooking and sewing. Needless to say, Cherokee women weren't terribly keen on giving up their economic power to be shackled to a kitchen.

Men were to pleased with being forced out of their own economic sphere of influence and onto the fields either. Many men, of course, did take up the plow themselves, but others preferred different means of farming without actually working the fields directly. One solution to this problem was to allow white sharecroppers to work the land for them. Another was to buy black slaves. Slavery wasn't unknown to the Cherokee prior to arrival of Europeans, but indigenous slavery was neither race-based nor hereditary. After a boom in the indigenous slave trade in the early 1700s, but the mid-1700s it was being phased out (not for particularly humanitarian reasons - mainly because the slavery wars had so thoroughly reshaped the demographics of the region that there wasn't anyone left that could easily be enslaved). Unfortunate the particular brand of "civilization" being pushed by Euroamericans did include racial, hereditary slavery and it did become popular among a minority of Cherokee, with only 209 Cherokee owning about 1600 slaves in 1835.

This minority was mostly composed of acculturated Cherokee with a recent Euroamerican ancestor (usually a father or grandfather). But not all mixed-race Cherokee were slave owners by any measure. At the time of Removal, about a quarter of the Cherokee Nation's citizens had mixed ancestry. Not-entirely-coincidentally, this was same proportion that had adopted Christianity. It's not an exact 1:1 match, but it was close. Missionaries had a much easier time with mixed-race families since 1) one parent was generally a Christian to begin with - if not both and 2) these families tended to live in more easily accessible areas of the Cherokee Nation.

I recommend checking out Theda Perdue's Cherokee Women for a relatively quick overview of the cultural transformation that took place among the Cherokee leading up to Removal.