I'm going to stick to direct descendants.

Ludwig van Beethoven died 1827, never married, no children. That's pretty direct, and I've never heard of any rumors of illegitimate offspring.

Wolfgang Amadeus Mozart died 1791, 6 children, but 4 died before he did. His only 2 surviving sons, Karl Thomas Mozart and Franz Xaver Wolfgang Mozart, both died unmarried and childless.

Pyotr Ilyich Tchaikovsky died 1893, married once (not a 'real' marriage), no children. He did have relations with women in his youth and was almost married, but it seems nothing ever came of it.