Not really no. Germany's usage of unrestricted submarine warfare pretty much made any changes to us policy a non starter. Even if we exclude the policy problems FDR faced with any involvement in WW2 let alone on the side seen as the aggressors by the population. Or his personal belief in the rightness of the Allies cause.

The same tactics that had so riled the US in WW1 were being used again. Indeed for months before December 7th the US Navy had been in an shooting war with the U-boat fleets. As part of the "Neutrality Patrol" they were under orders to sink any hostile combatant ship found on the American side of Atlantic. Though it was basically just a move to aid the Royal Navy.

There were losses on both sides as well a few U-boats sunk and for instance bthe Destroyer USS Reuben James was torpedoed and sunk in October of 1941.