Yes.

As the source describes, Milton was a republican in the historical sense. It was during his lifetime that Oliver Cromwell, still a divisive figure in English history, rose to power after overthrowing Charles I. Milton supported this. Charles I was deposed, but after returning and making war throughout the 1640s, the English ultimately executed him in 1649. Following this, Cromwell is given the title of Lord Protector of the realm, although after his death, the monarchy is restored bloodlessly. Although Richard Cromwell was selected to succeed, he did not command the requisite respect and was booted out of office within a year, leading to the restoration of Charles II to the throne.

Fast forwarding to 1667, after Milton (unpopular for his Republican views, at this point blind, which was considered by some to be divine punishment for his support of regicide, or the killing of the king.)

England in 1667 was reeling from the events of the previous year, when plague and fire had swept the capital, causing a devastation many people thought was divinely inspired; a biblical epic from a blind, grim old controversialist was by no means certain of being sympathetically received, as the poet's wish that his poem might 'fit audience find, though few' (VII.31) perhaps recognises. In spite of this unwelcoming climate, when Paradise Lost appeared, it was hailed as a work of genius, even by Milton's political opponents.

One of the first adaptations of the poem is John Dryden's play, which "outsold the original until the end of the seventeenth century."

Satan, who disdains servitude and tries to overturn his monarch, becomes in Dryden's rewriting an unmistakeable portrait of Oliver Cromwell, the king-killer. He also believed that the fallen angel, and not Adam, was the hero (in the sense of his structural position as the protagonist of the epic), and weighted his adaptation accordingly... Contemporary readers who thought there was a whiff of sulphur about the unrepentant republican poet were not surprised to find these sentiments in the mouth of the arch-fiend; and there were those who believed that Milton was in fact disowning his previous stance by associating it with Satan. Neither reading does justice to the complexity of Paradise Lost, but this does identify what was to become a recurrent theme in later responses to the poem: the contested interpretation of Satan, its eloquent anti-hero.

The most prominent later commenter on Milton who views Satan as the protagonist, William Blake, remarks that, "The reason Milton wrote in fetters when he wrote of Angels and God, and at liberty when of Devils and Hell, is because he was a true Poet and of the Devil's party without knowing it."

Essentially, opinions are divided: as the linked source would indicate, many at the time may have viewed Milton's poem as autobiographical in a sense, or as they say, that Milton was "disowning his previous stance by associating it with Satan." Those who favored Cromwell were likely to favor it; even those who didn't agree with Milton like his political opponents "hailed [it] as a work of genius." The role of Satan, then as now, was open to interpretation and disputation.

Source:

Peter Gaunt, Oliver Cromwell