While Ötzi the Iceman was roaming the Alps with his people there were already advanced civilizations in the Mediterranean basin and, as far as I know, people from the Neolithic were still somehow nomadic.
How likely is that someone like Ötzi encountered, or knew about one of the more advance civilizations like the Minoans, Egypt or Mesopotamia?
As no one has taken a stab at this, I'll give it a shot: it's extremely unlikely that a man living in the Po valley in 3300BCE would have access to many travelers who would have knowledge of the emerging polities of Egypt, Mesopotamia or even Crete.
First, he is thought to have lived his life over 100 miles from the nearest coastline, so even if maritime trade existed between the Minoans and the people living near the mouth of the Po, it's a big stretch to imagine that word of those civilizations would get to Otzi's people in any kind of useful form. Second (and most important, really) 3300BCE is centuries before the Minoan trade network was established, and even at it's height I've not found any hint that their network extended into the Adriatic, at least not past the borders of what is now Albania. There was certainly maritime activity during the period (somehow people managed to get to Crete) and there was probably some level of trade activity, but almost certainly not at the level necessary to bring word of Egypt to the Alps.
Finally, and not for nothing, there wasn't really much of an Egypt, Crete or Mesopotamia to talk about yet. Egypt was just on the cusp of being united for the first time, they were building structures called mastaba's to house the wealthy dead, these wouldn't evolve into pyramids for another 700 years. The great cities of Sumer were just a series of warring, proto-literate towns. I cannot speak to what Crete was like, but my understanding is that they were still confined to the local island group, and probably still in the stone- or early copper-age.