From a text that I had read on gender, the writer asserts that Androgen Insensitivity Syndrome, or AIS for short, do manifest in some characters, and some individuals with this genetic defect managed to become famous despite, and because, of this defect. Two examples are mentioned, Joan of Arc, and Queen Elizabeth the First.

Therefore, I would like to ask, is there any basis in fact for this claim that these significant characters have AIS? Furthermore, are there any historic examples of AIS that are proven? Lastly, if these notable individuals do have AIS, how were they able to carry on their lives even though they do have physical traits that are different from the normal individual?