For one, the food supply was not stable- not even from a regional farm to a city in the same region. We can dig up Roman Skeletons and a huge number show severe problems due to the problems of malnutrition. Everyone in Rome would not notice that many were shorter and had less muscle Mass then the Goths or other germanic tribes due to a lack of people who had criss-crossed the frontier adn back again. One of the things that affected daily life though, was the aristocracy realizing that the 'Empire' was one life support and it was time for them to stop paying taxes and start burying their wealth in order to prepare their family lineage and estates to succeed post-Empire.