Short Answer: Stanford

Longer Answer: The de facto home of the tech industry is the area known as "Silicon Valley," which is actually located south of San Francisco Bay in the northern half of Santa Clara County. This area includes the cities of San Jose, Sunnyvale, Cupertino, Mountain View, and Stanford.

Stanford fostered the growth of the tech industry in the surrounding area starting after WWII. In 1945, Frederick Terman took over as Dean of Stanford's School of Engineering, which was already home to many innovators in the fields of radio and electrical engineering. He encouraged engineering students to start businesses, and spearheaded a program to lease University land to high-tech companies. This paid off enormously as these companies would include Fairchild Semiconductor, Advanced Micro Devices, and Intel, who produced the rapid improvements in the silicon semiconductor industry on which the rest of the tech industry was and still is dependent.

The massive tech industry of Silicon Valley spills over into the surrounding area, and many workers and other companies are located in San Francisco, Oakland, and Berkeley.

As for your premise, San Francisco may have been the center of American counterculture for a few months in 1967 (the "Summer of Love), and has large pride parades every year, but for most people, that certainly isn't what the cultural, commercial, and financial center of Northern California is predominantly known for.