Throughout the history of Islamic scientific advancements of old there were cities that were the center of that advancement. What is shared between these cities is that they were outside of the Arabian Peninsula. Why hasn't Makkah or Madinah, the two holiest cities in Islam, become that center? A minority of the scholars that lead the scientific research else where were from the Arabian peninsula but it never happened in the peninsula itself . Anyone has an idea why is that the case ?
FYI, you don't need the "(serious)" tag on this sub. All questions and answers are taken seriously. Joke questions and joke answers are deleted.
The basic answer is that Mecca and Medina were backwaters. They ceased to be politically relevant as soon as more relevant population centers were captured. The overall populations of these cities was small. Medina was (briefly) a center of legal scholarship but would be eclipsed by Basra and Kufa as early as the 9th century. Baghdad, Cairo, Nishapur, Cordoba would be among the medieval centers of learning. Three of them were centers of political governance. All were major population centers and foci of regional and international trade.
I would also disabuse you of the notion of "scientific advancement" or "lead[ing] the scientific research". There was no such concept, and there was no such effort to lead. Islam produced and continued to produce scholars with an emphasis on science and medicine (among other subjects) but we're dealing with a pre-Baconian world where innovation and the conditions that enabled innovation were haphazard and diffuse, not directed and centralized.