Yes...but not in nearly a quarter-millennium. In 1783, the radical Charles Fox, a critic of monarchy in general and the Hanoverian dynasty in particular, teamed up with his old rival Lord North and formed a government with Fox as PM. King George III exerted all of his political influence to rally opposition to Fox in the House of Lords and, after a few victories, dissolved Parliament in 1784 in hopes of getting a more conservative government under William Pitt the Younger. Pitt won and Fox lost.