Yes.

There's the story of Leftraru (or Lautaro, transliterated into Spanish) from the Mapuche.

Leftraru was a child capted by the Spanish conquerors and made the personal squire of Pedro de Valdivia, conqueror and governor of Chile during the mid 1500s.

Given its position, he learned how to ride and not to fear horses, fight with European Spears and swords and shoot crossbows and firearms from the conquerors.

Eventually he fled and leaded a resistance against Valdivia himself. He taught what he learned from the Spanish to his people, then he stole horses and guns from Spanish forts. He trained them to form squads of cavalry to do shoot-and-run tactics, and taught infantry how to use pikes against cavalry charges. This developed into skirmishes and eventually full-blown battles.

In 1553 Valdivia and Leftraru fought in the hill of Tucapel, where the Spanish conquerors lost the battle and Valdivia himself was caught as his horse sunk into a swamp.

Valdivia was executed after the battle by the Mapuche warlords. Some sources say that Leftraru himself killed him and ate his heart. Others say that the warlords made him drink molten gold, as gold was the only thing conquerors wanted.

Six years later Leftraru died in the Battle of Mataquito, against the new Governor of Chile, Francisco de Villagra, but the rebellion didn't end.