Oh, yes! I have an earlier answer on "Renaissance women" bouncing off the idea of Leonardo da Vinci as a "Renaissance man" that might interest you. :D

But that post was narrow in scope to intellectual/polymath types. There were so many more ways that individual women made an impact! Religious leaders claiming gifts of ecstatic prophecy like bitter archrival nuns Domenica dal Paradiso and Dorotea da Lanciuole played active, even leading roles in post-Savonarolan religious politics--their feud spanned a decade and involved the entire city's mendicant community. Catherine of Genoa was a mystic who, more quietly, dictated her teachings to a circle of students.

Women also involved themselves in the flourishing art scene. Catherine of Bologna is probably the most famous one today. Antonia Pulchi was a playwright, composer, and lyricist of religious dramas and music that were performed in her native city of Florence.

And then, of course, there were the aristocrats and politicians. Even though women were barred from holding formal office and in Italy, specifically, were almost never heads of household, as mediators and as proxies for male relatives they wielded a surprising amount of indirect influence and direct power. Alfonsina Orsini ruled Florence from 1517-1519 during yet another period of male Medici exile from the city.

There are two important points to raise here. First, nearly all the standout women from Renaissance Italy we can point to were not married: they were nuns, tertiaries (informal nuns), or widows. With the intellectual/humanist women in particular, the sad pattern is a father providing his daughter the best education possible, she flourishes as a young woman author/philosopher/theologian--and as soon as she marries, ceases public literary activity.

Second, when we talk about "Renaissance" Italy, we are necessarily speaking primarily or exclusively of the upper crust. There are some women among the tertiaries who would have had a more middle class background. But in general, "the Renaissance" and its developments were an urban and elite phenomenon. We don't hear about peasant widows making great art or writing religious plays for their village confraternity.

Nevertheless, there are some really excellent stories based around phenomenal--for good or ill--women to come out of 15th-16th century Italy. And thanks to the literary grounding of its elite society, we can tell those stories in quite a bit of depth today.