Had Native American populations already drastically decreased prior to European Contact?

by HeshootsShescores

I vaguely remember a teacher telling me that either a war or influenza drastically decreased the Native American population shortly before the "Discovery of the New World", and this actually prevented the Native population from having the numbers to fight back. Does anyone have any sources for anything to support this claim or something similar?

Mictlantecuhtli

There's always room for discussion, but perhaps the section Disease in the Americas from our FAQ will answer your inquiry.