Caffa is in the Crimean Peninsula, which is like 2000 miles away from France where the Hundred Years' War was fought. I think it is safe to say that no, that was not part of the Hundred Year War. The siege did happen at the same time as the Hundred Years War, in 1346, but it had nothing to do with the French of English.

I'm not sure how to source a negative, but I scanned a couple of articles for anything about the Siege of Caffa and did not find any mention of the English, French, or the Hundred Years War except in the context of the Black Death.

OP, can you explain what possible connection you had in mind between the siege of Kaffa and the Hundred Years War? In other words, what led you to ask this question? Just curious.

HappensHappen I saw it on some of my sources I was using for a school project, but some of them didn't, though they were far away, but they were at a similar time. I was leaning towards no I just wanted to make sure.

Since the Hundred Years War was the largest war at that time resulting in many battles being linked to that in some way.