I was reading about Thomas Jefferson today and of the six children he had with his wife only two lived into adulthood and he outlived one of them as well. In my own family, my great-grandparents lost two of their seven children during childhood and it seems like it was treated as a sad but normal thing, unlike today. How did people "in the old days" deal with the high infant and child mortality rates?
Although it is a bit outside of your timeframe, you may be interested in /u/bigfridge224's answer on Infant mortality in the Roman Empire.