When early European settlers/explorers arrived in the Americas, the pathogens they brought with them and the impact those diseases had on the Native Americans was devastating (and pretty well documented). Why didn’t Native Americans spread diseases to Europeans that they had never been exposed to?
Not to discourage any further answers but you might enjoy these older posts:
Why weren't European settlers in North America decimated by disease like the native populations? by /u/400-rabbits
When Europeans brought diseases to the new world, how come Europeans themselves didn't get sick from diseases specific to the new world? by /u/anthropology_nerd