Not to discourage any further answers but you may find our FAQ on Disease in the Americas to be interesting. In particular, check out the sections on The Impact of European Diseases on the Aboriginal Population and Did the Europeans Deliberately Spread Disease?

These answers from the FAQ are particularly well-suited to your question:

What really happened in North America immediately before Columbus arrived? by /u/400-rabbits

Were there any actions that Mesoamerican civilizations could have reasonably taken to combat the spread of smallpox? by /u/400-rabbits

Were smallpox blankets really a thing? by /u/Reedstilt

Did Europeans intentionally spread diseases to Native Americans? Were they even aware of their actions? by /u/400-rabbits