I know Cahokia was a hub during its heyday, but haven't read anything more detailed about the routes than "there was a sophisticated network of trade routes connecting to X and Y places". Do we know enough to make decently-reliable maps like those we have for the Silk Road? What other hubs existed? Do we know anything about seasonal differences in route use? What sort of infrastructure did various cultures build along them?

Edit: I should specify that I mean north of Mesoamerica, since that's been addressed elsewhere on this forum.