I’m adapting an earlier answer of mine covering the conflicts in New York, Ohio, Missouri, and Illinois. But it mostly comes down to three things: Mormons were other with a capital “O,” a role they embraced. They were antagonistic. Smith frequently referred to non-Mormons in very derogatory language and would publish revelations promising the destruction of the heathens, and that their property would fall into Mormon hands. And finally they were seen as predatory, both sexually and economically. Because of this, the Mormons, especially their leader Joseph Smith, tended to run into problems wherever they landed.

Part 1 - New York

Let's start in upstate New York. As a teen Smith engaged in the profession of using a peep stone to look for buried treasure. He and his band of treasure hunters would hire themselves out to various people to dig for treasure on their land. Smith's role was that of the seer who would tell them where to dig, placate the spirits protecting the treasure, and to offer the excuses when no treasure was found. He was (likely) convicted at least once basically for being a disreputable character during this period. The word "conviction" is disputed, by the modern church, but he was taken to court, and paid a fine to the court, so it seems a reasonable description to me. The records are spotty. Before leaving New York he escaped from jail at least once, and was brought up on charges related to fraud and sexual misconduct... both of these will reoccur.

It's around this time he claimed to have found the gold plates. He then published the Book of Mormon as a translation of those plates, and founded what would become the LDS Church. It didn't take long before he was forced to flee to Ohio. Ultimately his persecution in this period came from three quarters

1- His band of treasure seekers. They took him at his word that he had found gold, and they wanted their cut as had been previously agreed. He came to understandings with a couple of them. But the rest were left in the cold. They resented that and made multiple attempts to steal the gold plates. This group is often conflated with the others below.

The Smith family records in their journals that their house and other nearby buildings being “mobbed” on several occasions by groups looking for the golden plates. They don’t mention that the mobs were generally made up of their friends and fellow con-artists. An interesting account is one that had Smith’s friend Willard Chase hiring his sister Sally Chase, a “seer” to look into her green stone to find the golden bible as they called it. She directed the mob over to a coopers shop across the way from the Smiths and told them the gold was buried beneath the floorboards. The group spent the entire night dismantling the shops before going away disappointed. But according to Smith they somehow missed the plates which he claimed were wrapped in flaxcloth and hidden in the rafters.

2- His creditors. Smith (and his family) in the period was a great borrower of money (and other things). He tended to be less good at returning what was lent. He was living and farming on borrowed land, planted with borrowed seed, using a borrowed magical peep stone, to translate his book, which was published with borrowed money. None of these (except the land) was ever returned. And the lenders were getting in some cases murderously impatient.

3- His family and neighbors. He had a reputation as a disreputable character. He was known as a shiftless layabout always working on some get rich quick scheme. He was also known as a no-good rake who was "ruining" the local girls. In fact he got his wife Emma Hale, by deducting and eloping with her. Ultimately his father-in-law, Isaac Hale, caught up to him, sat him down and read him the riot act. Smith in turn promised to reform and act honorably. Hale was a fairly successful farmer and lent Smith a home and enough farmland to make a go at it. But to Smith fly straight meant something different. It’s in this period that he began claim to be translating the Book of Mormon.

Founding a church and becoming a prophet was a bridge to far for a lot of them. Hale, the relatives of the Stowe girls, and others first tried to get him in court, and when he skated the charges they were gearing up for a good old fashioned lynching of one type or another. So he skipped town.