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While there is always more room for discussion on this question, we have a handy section on it in our FAQ.
Additionally, it is important to note the role that diseases played when it came to the depopulation of the Americas. It is true that in some case, disease did the majority of damage to certain Indigenous groups, disease alone is not responsible for many of the deaths that occurred. Rather, it was a combination of disease and colonization that resulted in the drastic losses of life. See these threads for reference: