When you consider the amount of resources Germany has versus their enemies (British Empire, Soviet Union, America, etc.) it should be fairly clear that they're outmatched in every single way relevant to conducting war, by a considerable margin too. This paper compares aircraft production of the major belligerents, and you'll notice that Germany's production was only slightly higher than the UK's, lower than the USSR's, and much, much lower than the US's. Bear in mind that Germany was fighting all three of them simultaneously. The author of that paper attributes that mainly to more primitive production methods, but they were short on important resources like oil:
To make matters worse, Germany was using far more of its fuel resources than had been calculated in the initial plans for BARBAROSSA. In the case of the Luftwaffe, fuel expenditures for the Soviet campaign were significant. In the first half of 1941 prior to the invasion, the Luftwaffe used an estimated 148 million gallons of aviation fuel. From June through December that amount more than doubled to 307 million, just slightly less than the 309 million gallons of fuel used by the Luftwaffe for the entire year in 1940.40 Total German production of aviation fuel in 1941 was only 326 million gallons—a significant deficit in light of the 456 million gallons used for the year. As a result, Luftwaffe fuel reserves fell dramatically from 219 million gallons in January 1941 down to 91 million by December. 4
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As you can probably imagine any prolonged war was a guaranteed loss, and the sheer scale of the war more or less guaranteed that it would be prolonged.
The only possible way I could see them "winning" is if they were a more "benign" authoritarian state that appealed to the Western powers' anti-Communist desires and actually tried a "hearts and minds" campaign on the people of Eastern Europe instead of genociding them, but at that point they're not really the Nazis anymore.
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