You have specified a rather brief period of time; in the few decades between when Penn was granted the land, in 1681 and 1710 the colony was a pretty small area centered on Philadelphia along the lower west bank of the Delaware river, across from New Jersey. They were not doing too badly, compared to the other North Atlantic colonies. Unlike the New England and Chesapeake colonies, William Penn and the Quakers were pretty successful in keeping on good terms with the Native American nations. They didn't have the awful death rate from "seasoning" ( probably malaria) further south in the Chesapeake Bay . There was some internal bickering and corruption ( Penn was himself honest but not too fiscally astute) but not as much as in Boston Bay and New York, and Penn's colony didn't have the religious turmoil of New England.
Still, life in the early colonies was mostly a pretty hard-scrabble affair, so if you liked books, music, theater, nice things and good intellectual conversation, you'd find it scarce. There was a good reason why Ben Franklin became quite wealthy as a writer and newspaper publisher- he had a very ready market! But perhaps one negative would be if you were a Pennsylvania farmer unlucky enough to settle on the very lower Delaware river, because that was an area that was also partially claimed by Maryland ( and much of it would eventually become the state of Delaware). You can see a map of it, circa 1719 here showing the extension. A large grant of land was made by Lord Calvert to Irishman Col. George Talbot about the time Penn was starting his colony, and Talbot was quite aggressive in asserting his rights. At one of Penn's council meetings ( April 3 1684) they read a letter from a Samuel Land
concerning Coll. Geo Talbot's goeing with three Musqueters to ye houses of Widow Ogle, Jonas Erskine & Andreis Tille, and tould them that if hey would not forthwith yield Obedieance to ye Lord Baltimore & Own him to be their Prop'or., and pay rent to him, he would turne them out of their houses and take their land from them.
Or another from Joseph Bowles on April 12th:
Coll. Talbot ridd up to his house and was ready to ride over him, and said Dam you, you Dogg, whom doe you Seat under here, you dogg! You seat under noe body; you have noe Warrt from Penn no my Lord, therefore, gett you gon, Else Ile sent you to St Mury': and I being frighted, Says he, you Brozen faced impudent Confident Dogg, Ile Sharten Penn's Territories by & by
Talbot not only quarreled with and threatened Pennsylvania settlers, but fought with a royal tax collector, killed him, was arrested, broke out of jail, fled, later got let off by the intercession of Calvert, went back to Ireland and fought on the losing (Catholic) side of the Battle of the Boyne, joined the "Wild Geese" fighting in the French army and died in Louis XIV's wars. A lively fellow, in other words.
There were quite a few incidents of this kind in the Atlantic colonies, as land grants and royal charters were handed out in England by monarchs who had no maps at their disposal. There would be substantial chaos of overlapping claims and jurisdictions in many of the colonies and the Maryland/Delaware/Pennsylvania border was much disputed ( some of the dispute is the basis for John Barth's classic satirical epic The Sot Weed Factor) There was a partial settlement in 1732, but even after the famous Mason Dixon survey in 1763 a small area called the Wedge was left unresolved until the 19th c. The Wedge seems to have long been convenient for smugglers, thieves and other fugitives from the law. So, if you settled in that region in 1710, you and your progeny might find yourself claimed by three states- or no state at all.
Alice Miller: Cecil County, Maryland