Before Hitler started invading various European countries, he took over Czechoslovakia as well which included Prague. I’ve never heard any stories of any Nazi leadership seeking to destroy it or even faking it to get Jews to give up hiding or as symbolism. Are there any reports about this happening?
No, Hitler did not try to look for the Golem. The Golem is a mythical being, not an actual entity that has existence in the physical world. In other words, there was nothing to look for.
Since we are talking about Nazi occupation of Prague, you might instead be interested in/u/hannahstohelit's story of the founding of the Jewish museum instead.