Did the Japanese ever resort to using biological and chemical warfare against the Americans during the Pacific War?

by J2quared
Georgy_K_Zhukov

They never brought out the chemical weapons, no. I touch on this a bit in this longer answer, but to reiterate, where there were a few scattered reports of individual grenades being used, these almost certainly were isolated incidents at best, and not a reflection of Japanese policy in the fight with the USA.