So this question is a tricky one, mainly because of a lack of a written record for Cahokia and other related cultures. We can see items being exchanged, but remember that Cahokia and Mississippian communities have prestige goods coming in from across the continent. Prestige goods were sought after for a range of reasons, and thus we can see an equally wide range of types of goods coming into Cahokia. The issue really is how direct was it, did the citizens of Cahokia know these goods were from regions like the fringes of mesoamerica? The trade could have been gradual, communities exchanging and repeating the process all the while goods travel far from the initial exchange. Or perhaps elites at Cahokia sought after goods from the Southwest specifically, or at least knew that those goods were obtained via an intermediary community somewhere along the way.

It is fair to note that there is little evidence to indicate that people were travelling between the American Bottom and Mesoamerica directly. We don't see individuals from either region in the archaeological record for the other. While lack of evidence is not the same as a solid no, a safe bet is that no one was directly travelling between the regions. But as for trade? That's a whole lot harder to narrow down, even if we did have a written record how well would the average Middle Mississippian have known the people's of Mesoamerica? Look at Samsung products today, many of us own them but how many of us here in the US know much about South Korea beyond it's geographic location? Sure we know they exist, but having trade goods from them really only shows that we like the items they produce without any sort of written record to explain the relationship between the average American and average Korean. You need that record to help build some of the explanations that the archaeological record struggles to do at times.