I came across a reference that Shakespeare made up the word 'quarrel', and he's certainly famous for originating many new words. Is that just because he wrote them down as dialogue, but people used them all the time? If they were truly original, how would people have understood them? Purely through context clues, or were they often plays on other known words?
There's always more to be said, but you may be interested in /u/cdesmoulins's answer to If William Shakespeare made up new words for his works, how did contemporary playgoers understand his dialogue, /u/Yst's answer to How did Shakespeare invent words in his plays? Did the audience understand the meanings of the words which he invented? and /u/texpeare's answer to Did Shakespeare really "invent" all of the words and phrases he purportedly did, or did his work just contain the first written record of them?.