The alternate history of the Romans discovering gun powder and using it on invading barbarians is a common one, however when Constantinople fell in 1453, gunpowder was already used in cannon and very early muskets. Do we have any record of Byzantines using gunpowder based weapons?

by Redsoxjake14
DericStrider

More can be said on this subject. This answer by /u/manfrin should give some answers to your question.