If you ignore the morality of treating people like farm animals, and only look at economics, it would have been very difficult for the Southern states to have abolished the basis of their economy, even if they had wanted to. One could draw a parallel to the modern use of fossil fuels. Is there evidence that voluntary abolition was ever a realistic possibility?
The following specific questions may help define what seems a "realistic possibility", if that needs to be narrowed down:
Just noting, /r/AskHistorians has a lot of good info in its FAQ on the American Civil War.
And you may find answers to a few of your questions in this thread started by /u/b3048099
Good answers from /u/Georgy_K_Zhukov