I was reading about the Iroquois confederacy and it seems kind of similar to the US states, a system of federalism with the gens.
You may appreciate an answer I provided to the question [Various writers who write from or sympathize with perspective(s) of indigenous people in America and abroad have suggested that the political structure of the Iroquois confederacy had a consequential influence on the Federal structure of the US Constitution. Is there evidence to affirm this idea ?] (https://www.reddit.com/r/AskHistorians/comments/iyvarp/various_writers_who_write_from_or_sympathize_with/) not too long ago. It depends on your context of how - if you mean what actions did the influencing, the list is long: common defense, legislative oversight, some balance/checks on power, a central executive, power of impeachment, state sovereignty, the ability to grow the confederation through admission of new "states", etc. If you mean how did the influencing happen chronologically, it largely has to do with two men - a Native cheif of the Onondaga Nation named Canassatego and a British colonist named Ben Franklin, as detailed in my link.
The founders surely were not alien to the concepts of the native Confederations, of which the Six Nations was the largest. Native Confederations existed in New England when the Pilgrams showed up and Powhatan was the leader of a pretty large one in Virginia when the Jamestown folks got there.
For a more in depth look at the relation of the Six Nations and our founding documents, as well as the claims made about these relations by various historians, [The Iroquois League, the Articles of Confederation, and the Constitution by Samuel B. Payne, Jr. published in The William and Mary Quarterly Vol. 53, No. 3, "Indians and Others in Early America" (Jul., 1996), pp. 605-620 (16 pages)] (https://www.jstor.org/stable/2947207?seq=1#metadata_info_tab_contents) is a great (free) read on the topic. (I don't agree with their overall conclusion, but they lay out the overall facts quite well and provide a good review of the opinions of professionals.)