Not particularly, relative to many other postcolonial African states. I haven't seen the show in question, but the character as described here feels like he's making a more generically pan-African, postcolonial point about the US role in the world and in sub-Saharan Africa during the Cold War and afterwards rather than speaking about a specific incident or episode in Nigerian history. Nigeria was certainly subjected to the same attention and pressures as most postcolonial African states amplified by its economic and political importance in West Africa.

The only specific events or episodes that a Nigerian character might have in mind as involving the US would be the Biafran War (where one region of Nigeria attempted to declare its independence), but the US did not play an outsized role in the unfolding or resolution of that crisis, or the US interest in oil production in the Niger Delta, which the US has definitely been keenly interested in and concerned about. The US also played a somewhat complicated role in the rule of the military leader Sani Abacha, but not really in a fashion that you could characterize as imperialist per se. And the US in more recent years has taken a military interest in the Islamist insurgency known as Boko Haram, but that's very much a post-Cold War issue.