This is a big question less because of the timescale and geographic scope, and more because of the different layers of potential meaning here.

On the most basic, no, queens regnant were not subjected to verbal abuse or browbeating from advisors on the basis that their gender made them subordinate to high-ranking male subjects, or ridiculed by middle-class and working-class subjects for presuming to take a male position - at least any of those I'm aware of.

But then there's a level up, where I must explain that yes, sexism came into play. In the early middle ages, the idea of a woman inheriting a throne in western Europe was just not thought of, and by the high middle ages women who inherited were typically inheriting in name only, passing the throne on to a husband or son. We don't really see women inheriting and then ruling in just the same way as a man would until the late middle ages, although once it started to happen it was soon normalized as something that the queens had a right to, when there were no male heirs in their immediate families. But these queens (and those that followed them) did still have to deal with gendered expectations.

I've discussed these issues in several past answers:

Did ruling Queens in historical Europe face gender discrimination?

When Isabella and Ferdinand joined the houses of Castile and Aragon, they ruled as practically equals. Was it unusual for a queen to wield such political power and influence in 15th Century Europe; and what did contemporaries write about the extent of Isabella’s power and influence over Spain?

How were Female rulers Like Catherine the Great and Queen Victoria seen as capable of ruling when women in those days were thought of as lesser than men.

Mary Tudor was the first queen regent of England. Was this noted at the time? Was there any significant reaction, positive or negative, to having a solo female ruler?

Why did Londoners reject Empress Matilda in 1141?

On Berenguela of Castile

What Happened in the Late Middle Ages that Suddenly Allowed Queens to Be More Palatable for the Ruling Class in the UK to Support as Regent?

How would Royal marriages work, in respect of governance, when the two participants were both ruling monarchs in their own rights?

Were women monarchs as respected as their male counterparts?

You're not really asking about consorts, but they faced similar issues: they were not straightforwardly told "you have no power, you're just a woman," but they very much faced backlash when they were perceived to be acting outside of their roles. I've discussed them in these past answers:

History of Queen Consorts?

Margaret D’Anjou and Henry VI

What did the French people think about Marie Antoinette before she became the queen.